This Automated Library Preparation System (ALPS) was designed as a stand-alone tabletop unit that includes all standard library prep components to enable library prep for molecular diagnostics in a space-efficient format. This small package library preparation system delivers a fully automated assay workflow, providing process efficiencies and improved systematic liquid handling accuracy. The user places consumables (which Simplexity has also designed) in the system and the system delivers a processed sample, ready for sequencing. Harnessing our expertise in printer drive train assemblies, this unit delivers a viable lower cost solution to an expanding market sector.

THE PRODUCT

• A sophisticated breadboard incorporating all steps of a standard Library Prep (LP) workflow for Next Generation Sequencing (NGS)​
• Used to perform guard band studies and de-risk automation of the Library Prep Assay Protocol before green lighting final product development ​
• Includes integrated stations for standard 96 wellplate​
  • Thermocycler​
  • Non-contact Dispense array​
  • Reagent management system​
  • Aspiration/Waste management station​
  • Bead removal station​
  • Embedded motion system to move between all stations​
  • Dedicated, on demand pressure and vacuum supply system​

OUR ROLE 

• Work closely with the client design team to integrate early, single station breadboard designs from the client with our own original designs and combine them in a single, integrated ​
• Develop production level consumables for testing in the system along with fixtures and protocols for their assembly​
• Generate API for both independent control and integration with other lab automation tools